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Quantitative Imaging for Bone and Joint Research

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Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo

Published in Front. Bioeng. Biotechnol., 2021

Despite steadily improving treatments for bone diseases, prescribed therapies are not always successful in certain patients.

Recommended citation: Walle M, Marques FC, Ohs N, Blauth M, Müller R and Collins CJ (2021) Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo. Front. Bioeng. Biotechnol. 9:677985. doi: 10.3389/fbioe.2021.677985 https://www.frontiersin.org/articles/10.3389/fbioe.2021.677985/full

Meta-analysis of diabetes mellitus-associated differences in bone structure assessed by high-resolution peripheral quantitative computed tomography.

Published in Current Osteoporosis Reports, 2022

Diabetes leads to higher blood sugar and changes in how the body can process sugar.

Recommended citation: Whittier DE, Frost M, Müller R, Collins CJ. Meta-analysis of diabetes mellitus-associated differences in bone structure assessed by high-resolution peripheral quantitative computed tomography. Current Osteoporosis Reports. 2022 Dec;20(6):398-409. https://link.springer.com/article/10.1007/s11914-022-00755-6

Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks.

Published in Bone, 2023

When patients move during a specific type of bone scan called high-resolution peripheral quantitative CT (HR-pQCT), it reduces the quality of the images.

Recommended citation: Walle M, Eggemann D, Atkins PR, Kendall JJ, Stock K, Müller R, Collins CJ. Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks. Bone. 2023 Jan 1;166:116607. https://www.sciencedirect.com/science/article/pii/S8756328222002848

Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo.

Published in Bone, 2023

Local mechanical forces in bone play an important role in bone health and adaptation.

Recommended citation: Walle M, Whittier DE, Schenk D, Atkins PR, Blauth M, Zysset P, Lippuner K, Müller R, Collins CJ. Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo. Bone. 2023 Jul 1;172:116780. https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(23)00113-8

Bone remodelling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus.

Published in Journal of Bone and Mineral Research, 2024

Recent studies indicate that type 1 diabetes mellitus impairs bone remodeling by reducing the skeleton’s responsiveness to mechanical stimuli, leading to significantly lower bone formation and resorption rates compared to healthy controls.

Recommended citation: Walle M, Duseja A, Whittier DE, Vilaca T Paggiosi M, Eastell R, Müller R, Collins CJ. Bone remodelling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus. Journal of Bone and Mineral Research https://doi.org/10.1093/jbmr/zjad014

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