CV
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MATTHIAS WALLE (he/him)
(BSc., MSc., PhD., E.I.T.)
Dr. sc. ETH Zürich — McCaig Institute, University of Calgary, Canada
matthias.walle@ucalgary.ca wallematthias.github.io LinkedIn Google Scholar
PERSONAL INFORMATION
Language Certificates German: C2. Abitur (native) English: C1. German Academic Exchange Service (DAAD) French: B1. Diplôme d'études en langue française (DELF) | 07/13 07/19 06/11 |
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Nationality German
Work permits European Union, Canada (work permit, applying for permanent residency)
ORCiD 0000-0003-3250-8143
EDUCATION
ETH Zürich Doctoral studies (Dr. sc. ETH Zürich) Department of Health Sciences and Technology supervised by Prof. Dr. Ralph Müller. | 03/20 – 09/23 |
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Technical University Munich Master of Science (M.Sc., Dipl.-Ing.) Mechanical Engineering. Bachelor of Science (B.Sc.) Mechanical Engineering. | 08/17 – 02/20 10/13 – 07/17 |
Research stays abroad
| 06/23 – 09/23 11/22 – 11/22 08/21 – 12/21 08/19 – 01/20 03/19 – 07/19 08/18 – 12/18 |
RESEARCH EXPERIENCES
Postdoctoral Fellowship, McCaig Institute, University of Calgary. Digital analysis of bone remodelling to understand the effects of high-dose vitamin D supplementation.
| 10/23 – 10/25 |
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Doctoral Studies, Institute for Biomechanics, ETH Zürich. Mechanoregulation of bone remodelling in diabetes mellitus using HR-pQCT in vivo patient data.
| 03/20 – 09/23 |
Master’s Thesis, Beth Israel Deaconess Medical Center, Harvard Medical School. Effects of microscopic spatial complexity and heterogeneity on trabecular bone modulus.
| 08/19 – 01/20 |
Bachelor’s Thesis, Institute of Micro Technology and Medical Device Technology, TU Munich. A relational database for medical device certification.
| 11/17 – 02/18 |
PROFESSIONAL INDUSTRY EXPERIENCES
Intern at Aesculap AG, Front End Innovation.
| 04/17 – 10/17 |
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Software Engineer at MathWorks, Technical Support.
| 10/16 – 03/17 |
GRANTS, FELLOWSHIPS, AWARDS
Grants
| 08/24 $20000 |
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| 04/23 – 08/23 $77200 |
| 01/25 – 12/26 $75000 |
Scholarships and fellowships
| 10/23 – 09/25 $140000 |
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| 01/20 – 12/23 €187000 |
| 08/18 – 12/18 CHF 2200 |
| 04/18 – 07/19 € 3600 |
Awards
| 11/2024 CHF 2000 |
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| 07/24 09/2024 US-$ 1000 |
| 10/2024 US-$ 1500 |
| 08/23 C-$1000 |
| 07/20 €300 |
TEACHING EXPERIENCE
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| 10/16 – 03/17 |
Guest lectures
| 03/24 |
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| 11/23 |
ADVISORY AND SUPERVISORY RESPONSIBILITIES
Teaching assistants
| 02/21 – 05/22 |
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| 02/21 – 05/22 |
| 02/21 – 05/22 |
| 02/21 – 05/21 |
| 02/21 – 05/21 |
Scientific supervision
| 05/22 – 08/22 |
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| 03/22 – 09/22 |
| 02/22 – 05/22 |
| 10/21 – 05/22 |
| 08/21 – 05/22 |
| 10/21 – 02/22 |
| 07/21 – 10/21 |
| 06/21 – 12/21 |
| 05/21 – 07/21 |
| 02/21 – 05/21 |
| 02/21 – 06/21 |
ACADEMIC CITIZEN- AND LEADERSHIP
Institutional service
| 24-25 |
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| 24-Present |
| 24-Present |
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| 23-Present |
| 22-Present |
| 22-24 |
Active professional society memberships
| 25-Present |
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| 20-24 |
| 20-24 |
| 20-Present |
| 23-Present |
Peer review contributions
| 23-Present |
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| 23-Present |
| 22-Present |
| 22-Present |
Other leadership roles
| 11/24 |
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| 11/24 |
| 09/24 |
| 07/24 |
| 05/24 |
| 04/24 |
| 05/24 |
Professional development and training activities
| 01/24 |
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| 02/22 |
| 04/22 |
| 02/22 |
| 11/21 |
| 09/21 |
| 03/21 |
| 09/20 |
| 12/20 |
| 08/20 |
| 07/20 |
| 06/18 |
| 09/13 |
Research engagement activities (presentations for research, industry, and clinical audiences)
| 04/5 |
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| 04/25 |
| 05/24 |
| 11/23 |
| 10/23 |
| 04/23 |
| 06/22 |
| 05/22 |
| 11/21 |
| 07/21 |
| 04/21 |
OUTREACH
| 01/25 |
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| 01/25 |
| 09/24 |
| 07/24 |
| 12/22 |
| 05/22 |
| 05/22 |
| 02/22 |
| 09/21 |
| 09/21 |
| 06/21 |
INVITED RESEARCH TALKS
M. Walle. Mechanoregulation of bone remodelling in diabetes using HR-pQCT in vivo patient data. Invited Speaker, 50th Annual European Calcified Tissue Society Congress (ECTS 2023), Open Forum: type 1 and 2 diabetes and bone health - results from the FIDELIO research training network, Liverpool, UK, 05/2023.
PEER-REVIEWED PUBLICATIONS
Original articles
D.E. Whittier, M. Walle, P.R. Atkins, C.J. Collins, M.A. Zumstein, P. Christen, K. Lippuner, R. Müller. Structural alterations during fracture healing lead to void spaces developing in surrounding bone microarchitecture. JBMR, 2025.
M. Walle, L. Gabel, D.E. Whittier, A. Liphardt, P.A. Hulme, M. Heer, S.R. Zwart, S.M. Smith, J.D. Sibonga, S.K. Boyd. Tracking of spaceflight-induced bone remodeling reveals a limited time frame for recovery of resorption sites in humans. Science Advances.
M. Walle, D. Yeritsyan, M. Abbasian, R. Oftadeh, R. Müller, A. Nazarian. A graph model to describe the network connectivity of trabecular plates and rods. Front. Bioeng. Biotechnol., 2024.
M. Walle, A. Duseja, D.E. Whittier, T. Vilaca, M. Paggiosi, R. Eastell, R. Müller, C.J. Collins. Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus. JBMR, 2024.
V. B. Kassey, M. Walle, J. Egan, D. Yeritsyan, I. Beeram, Y. Wu , B.D. Snyder, E.K. Rodriguez, J.L. Ackerman, A. Nazarian. Quantitative 1H magnetic resonance imaging on pathologic rat bones by solid-state 1H ZTE sequence with water and fat suppression. Journal of Magnetic Resonance Imaging, JMRI, 2024.
V.B. Kassey, M. Walle, J. Egan, D. Yeritsyan, I. Beeram, Y. Wu , B.D. Snyder, E.K. Rodriguez, J.L. Ackerman, A. Nazarian. Quantitative 31P Magnetic resonance imaging on pathologic rat bones by ZTE sequence at 7T. Bone, 2024.
D.E. Whittier*, M. Walle*, D. Schenk, P.R. Atkins, C.J. Collins, P. Zysset, K. Lippuner, R. Müller. A multi-stackregistration technique to improve measurement accuracy and precision across longitudinal HR-pQCT scans. Bone, 2023. (*equal contribution).
M. Walle, D.E. Whittier, D. Schenk, P.R. Atkins, P. Christen, M. Blauth, P. Zysset, K. Lippuner, R. Müller, C.J. Collins. Precision of bone mechanoregulation assessment using longitudinal HR-pQCT. Bone, 2023.
F.C. Marques, D. Boaretti, M. Walle, A.C. Scheuren, F.A. Schulte, R. Müller. Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency. Front. Bioeng. Biotechnol, 2023.
M. Walle, D. Eggemann, P.R. Atkins, K. J.J. Kendall, Stock, R. Müller, C.J. Collins. Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks. Bone, 2022.
M. Walle, D.E. Whittier, M. Frost, R. Müller, C.J. Collins. Meta-analysis of diabetes mellitus-associated differences in bone structure assessed by high-resolution peripheral quantitative computed tomography. Curr. Ost. Rep., 2022.
M. Walle, F.C. Marques, N. Ohs, M. Blauth, R. Müller and C.J. Collins. Bone mechanoregulation allows subject-specific load estimation based on time-lapsed micro-CT and HR-pQCT in Vivo. Front. Bioeng. Biotechnol., 2021.
A. Malhotra, M. Walle, G.R. Paul, G.A. Kuhn and R.Müller. Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect. Sci. Rep., 2021.
Book chapters
M. Walle, B.E. Matheson, S.K. Boyd, Quantitative outcomes from computed tomography: Technical challenges and clinical advances. In L. Cardoso, J.-F. Ganghoffer, & M.B. Schaffler (Eds.), Biomechanics and mechanobiology of bone: From model to patient (Chapter 5.4). Springer. (in submission).
Original articles in submission (manuscripts can be provided on request)
V.B. Kassey, M. Walle, J. Egan, D. Yeritsyan, I. Beeram, Y. Wu , B.D. Snyder, E.K. Rodriguez, J.L. Ackerman, A. Nazarian. A versatile double-tuned rf probe-head design to quantify MR-based bone matrix and mineral densities in rat bones. In submission JMRI, 2025.
B.E. Matheson, M. Walle, L. Gabel, A. Liphardt, P.A. Hulme, M. Heer, S.R. Zwart, S.M. Smith, J.D. Sibonga, S.K. Boyd. Recovery of Bone Microarchitecture and Density Four Years After Spaceflight. In submission npj microgravity, 2025.
A.R. Bugbird, B.E. Matheson, M. Walle, N.J. Neeteson, N. Pavlovic, C.E. Stirling, D.E. Whittier, and S.K. Boyd. Quantifying Localized Bone Loss in Clinical Computed Tomography using Void Spaces. In submission JBMR, 2025
M. Walle, B.E. Matheson, S.K. Boyd. Comparing Linear and Nonlinear Finite Element Models of Vertebral Strength Across the Thoracolumbar Spine: A Benchmark from Density-Calibrated Computed Tomography. bioRxiv (2025): 2025-04. (In submission GigaScience, 2025)
PEER-REVIEWED CONFERENCE ABSTRACTS
Oral podium presentations
B.E. Matheson, M. Walle, C. Ye, S.K. Boyd. Investigating bone density and strength across sex and age using machine learning and finite element modeling. Submitted to the European Society of Biomechanics. Zürich, Switzerland, July 6-9, 2025.
B.E. Matheson, M. Walle, L. Gabel, A. Liphardt, P.A. Hulme, M. Heer, S.R. Zwart, S.M. Smith, J.D. Sibonga, S.K. Boyd. Recovery of Bone Microarchitecture and Density Four Years After Spaceflight. Submitted to the European Society of Biomechanics. Zürich, Switzerland, July 6-9, 2025.
M. Walle, L. Gabel, D.E. Whittier, A. Liphardt, P.A. Hulme, M. Heer, S.R. Zwart, S.M. Smith, J.D. Sibonga, S.K. Boyd. Investigating the time-dependent recovery of spaceflight-induced bone resorption in astronauts. 16th Congress of the International Society of Bone Morphometry, Toronto, ON, Canada, October 3-6, 2024.
M. Walle, L. Gabel, D.E. Whittier, A. Liphardt, P.A. Hulme, M. Heer, S.R. Zwart, S.M. Smith, J.D. Sibonga, S.K. Boyd. Investigating the time-dependent recovery of spaceflight-induced bone resorption in astronauts. ASBMR, Toronto, ON, Canada, September 27-30, 2024.
M. Walle, L. Gabel, D.E. Whittier, A. Liphardt, P.A. Hulme, M. Heer, S.R. Zwart, S.M. Smith, J.D. Sibonga, S.K. Boyd. Timelapsed HR-pQCT of local remodelling sites reveals coupling of bone formation and resorption sites during spaceflight and recovery of Earth. The 24th International Workshop on Quantitative Musculoskeletal Imaging, The Barossa Valley, South Australia November 3-8, 2024.
M. Walle, D.E. Whittier, S.K. Boyd, R. Müller and C. J. Collins. Measuring bone remodelling in vivo: does voxel size really matter? Annual Alberta Biomedical Engineering Conference 2023, Banff, Alberta, Canada, 2023.
M. Walle, D. Eggemann, P.R. Atkins, K. Stock, R. Müller, C.J. Collins. Integration of artificial intelligence into diagnostic imaging: convolutional neural network-supported HR-pQCT visual grading. 9th World Congress of Biomechanics, July 10-14, 2022, Taipei, Taiwan.
P. Y. Steiner, M. Walle, M. Rigotti, D.E. Whittier, C. McLennan, P. R. Atkins, R. Müller, C. J. Collins. Correction of motion artefacts in HR-pQCT using cycle-consistent adversarial networks. Abstracts 27th Congress of the European Society of Biomechanics, Porto, Portugal, June 26-29, 2022.
D.E. Whittier, M. Walle, P. Christen, P.R. Atkins, C. Collins, M. Blauth, K. Lippuner, R. Müller. Changes in loading during fracture healing do not impact bone microarchitecture of the unfractured wrist. Abstracts 27th Congress of the European Society of Biomechanics (ESB), Porto, Portugal, June 26-29, 2022.
M. Walle, D.E. Whittier, C. Weidlich, D.O. Windisch, P.R. Atkins, P. Christen, M. Blauth, K. Lippuner, R. Müller, C.J. Collins. Time-lapsed HR-pQCT allows monitoring local bone remodelling events at various follow-up time-points in vivo. The 23rd International Workshop on Quantitative Musculoskeletal Imaging, June 13-17, 2022, Noordwijk, Netherlands.
M. Walle, F.C. Marques, N. Ohs, M. Blauth, R. Müller and C. J. Collins. Bone mechanoregulation allows subject-specific in vivo estimation of microstructural tissue loading history. 26th Congress of the European Society of Biomechanics, July 11-14, 2021, Milan, Italy.
Flash podium/hybrid presentations
D.E. Whittier, M. Walle, C. Ledoux, P.R. Atkins, C.J. Collins, J.A. Holtmann, M.A. Zumstein, P. Christen, K. Lippuner, R. Müller. fracture healing leads to localized structural bone loss quantified using void space analysis. Abstracts ASBMR 2023 Annual Meeting, Vancouver, Canada, J. Bone Miner. Res., 2023.
M. Walle, D.E. Whittier, D. Schenk, M. Blauth, P. Zysset, K. Lippuner, R. Müller, C.J. Collins. In vivo repeatability of bone mechanoregulation assessment using longitudinal high-resolution peripheral quantitative computed tomography. Abstracts 50th Annual European Calcified Tissue Society Congress, Liverpool, UK, 05/15-18, JBMR Plus: Volume 7, Issue S3, 2023.
D.E. Whittier, M. Walle, C. Ledoux, J. Holtmann, C.J. Collins, K. Lippuner, R. Müller. Early bone remodelling during fracture healing measured by HR-pQCT is a determinant of long-term bone mineral density. Abstracts 50th Annual European Calcified Tissue Society Congress, Liverpool, UK, 05/15-18, JBMR Plus: Volume 7, Issue S3, 2023.
M. Walle, D. Whittier, R. Müller, C.J. Collins. HR-pQCT measures of bone microarchitecture in type 1 and type 2 diabetes mellitus: systematic review and meta-analysis. European Calcified Tissue Society Congress 2022, 07-10 May, 2022, Helsinki, Finland.
M. Walle, M. Abbasian, D. Yeritsyan, R. Oftadeh, A. Nazarian. plate and rod networks describe load transfer in trabecular bone. 26th Congress of the European Society of Biomechanics, July 11-14, 2021, Milan, Italy.
M. Walle, F. C. Marques, N. Ohs, R. Müller, and C. J. Collins. 3D physiological load estimation based on time-lapsed HR-pQCT images. Abstracts ASBMR 2020 Annual Meeting, Seattle, USA, J. Bone Miner. Res., 2020.
Poster presentations
M. Walle, B. Matheson, A. Abbott, C. Ye, M. Monument, S.K. Boyd. Non-invasive automatic assessment of vertebral strength in cancer patients with and without bone metastasis. ASBMR, Toronto, ON, Canada, September 27-30, 2024.
M. Walle, A. Duseja, D.E. Whittier, T. Vilaca, M. Paggiosi, R. Eastell, R. Müller, C.J. Collins. Bone remodelling and responsiveness to mechanical stimuli in type 1 diabetes mellitus: the role of neuropathy. Abstracts ASBMR 2023 Annual Meeting, Vancouver, Canada, J. Bone Miner. Res., 2023.
V. Kassey, M. Walle, J. Egan, D. Yeritsyan, Y. Wu, B.D. Snyder, E.K. Rodriguez, J.L. Ackerman and A. Nazarian. A versatile MRI post-processing package with graphical user interface in MATLAB. 63rd ENC, April 24-29, 2022, Orlando, Florida, USA.
M. Walle, D. Eggemann, P.R. Atkins, K. Stock, Müller, C.J. Collins. Operator-independent characterisation of image quality in HR-pQCT scans using a fully automated convolutional neural network-based classification method. ORS 2022 Annual Meeting, February 4 – 8, 2022, Tampa, Florida, USA.
V. Kassey, M. Walle, J. Egan, D. Yeritsyan, Y. Wu, B. Snyder, E. Rodriguez, J. Ackerman, A. Nazarian. A combined solid-state 1H and 31P magnetic resonance imaging to assess bone mineral and matrix densities in rat bones. Abstracts 2021 ISMRM & SMRT Annual Meeting, International Society for Magnetic Resonance in Medicine.
D. Eggemann, M. Walle, P. Atkins, K. Stock, R. Müller, and C. J. Collins. Operator-independent characterization of image quality in HR-pQCT scans using a fully automated convolutional neural network-based classification method. Abstracts ASBMR 2021 Annual Meeting, Toronto, Canada, J. Bone Miner. Res., 2021.
M. Walle, F. C. Marques, N. Ohs, M. Blauth, R. Müller and C. J. Collins. Tissue-level mechanical stimuli drive bone formation and resorption in humans and mice. Digital Congress of the European Calcified Tissue Society, 05/6-8, 2021, online.
Abstracts in submission
B.E. Matheson, M. Walle, C. Ye, S.K. Boyd. From Incidental to Intentional: Unlocking Bone Health Insights from Routine CT Data. Radiological Society of North America Annual Meeting 2025. Nov. 30 – Dec. 4, 2025, Chicago, USA. Submitted.