Matthias Walle
Postdoctoral associate in bone imaging, AI, and scientific software
I am a postdoctoral associate at the McCaig Institute, University of Calgary. My work connects mechanobiology, musculoskeletal imaging, and computational methods, with a focus on longitudinal HR-pQCT, opportunistic CT, vertebral strength assessment, and translational research software that stays useful beyond a single paper.
Before Calgary, I completed my doctorate at ETH Zurich on mechanoregulation of bone remodelling in diabetes. Across projects, I build imaging methods, quantitative pipelines, and open tools that help turn complex skeletal data into interpretable, reproducible measurements.
Methods for mapping bone formation and resorption relative to local mechanical environment.
Applications in altered loading, metabolic disease, spaceflight, fracture healing, and routine CT.
Open pipelines, CLI tools, and reproducible workflows designed for real imaging datasets and collaboration.
Public repositories, datasets, trainee support, and methods that remain understandable after publication.
I develop quantitative imaging methods for bone structure, strength, and remodelling across longitudinal HR-pQCT, opportunistic CT, and finite element modelling workflows.
Much of the research lives as software. I build practical codebases that collaborators can run, inspect, validate, and extend.
Alongside research, I contribute teaching materials, public datasets, mentorship, and collaborative workflows that support more reproducible musculoskeletal imaging science.