Research

My research sits at the intersection of image analysis, musculoskeletal imaging, biomechanics, and scientific computing. I currently work on opportunistic CT for vertebral strength assessment and quality control, while continuing long-running work on HR-pQCT-based remodelling analysis, mechanoregulation, and spaceflight-related bone change.

Research Highlights

Comparing linear and nonlinear finite element models of vertebral strength across the thoracolumbar spine: a benchmark from density-calibrated computed tomography

Matthias Walle, Bryn E Matheson, Steven K Boyd

GigaScience · 06 Jan 2025 · doi:10.1093/gigascience/giaf094

Tracking of spaceflight-induced bone remodeling reveals a limited time frame for recovery of resorption sites in humans

Matthias Walle, Leigh Gabel, Danielle E. Whittier, Anna-Maria Liphardt, Paul A. Hulme, Martina Heer, Sara R. Zwart, Scott M. Smith, Jean D. Sibonga, Steven K. Boyd

Science Advances · 20 Dec 2024 · doi:10.1126/sciadv.adq3632

A graph model to describe the network connectivity of trabecular plates and rods

Matthias Walle, Diana Yeritsyan, Mohammadreza Abbasian, Ramin Oftadeh, Ralph Müller, Ara Nazarian

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY · 01 Jan 2024 · doi:10.3389/FBIOE.2024.1384280

Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus

Matthias Walle, Ankita Duseja, Danielle E Whittier, Tatiane Vilaca, Margaret Paggiosi, Richard Eastell, Ralph Müller, Caitlyn J Collins

JOURNAL OF BONE AND MINERAL RESEARCH · 01 Jan 2024 · doi:10.1093/JBMR/ZJAD014

Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks

Matthias Walle, Dominic Eggemann, Penny R. Atkins, Jack J. Kendall, Kerstin Stock, Ralph Müller, Caitlyn J. Collins

BONE · 01 Jan 2023 · doi:10.1016/J.BONE.2022.116607

Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo

Matthias Walle, Danielle E. Whittier, Denis Schenk, Penny R. Atkins, Michael Blauth, Philippe Zysset, Kurt Lippuner, Ralph Müller, Caitlyn J. Collins

BONE · 01 Jan 2023 · doi:10.1016/J.BONE.2023.116780

Meta-analysis of Diabetes Mellitus-Associated Differences in Bone Structure Assessed by High-Resolution Peripheral Quantitative Computed Tomography

Matthias Walle, Danielle E. Whittier, Morten Frost, Ralph Müller, Caitlyn J. Collins

CURRENT OSTEOPOROSIS REPORTS · 01 Jan 2022 · doi:10.1007/S11914-022-00755-6

Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo

Matthias Walle, Francisco C. Marques, Nicholas Ohs, Michael Blauth, Ralph Müller, Caitlyn J. Collins

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY · 01 Jan 2021 · doi:10.3389/FBIOE.2021.677985

Publication List

19 works

2026

Association of immune checkpoint inhibitors with muscle mass and density in patients with melanoma

Susan Ziolkowski, Bryn E Matheson, Steven K Boyd, Matthias Walle, Jasmine Gill, John Walker, Thomas Salopek, Joshua F Baker, Ates Fettahoglu, Carrie Ye

The Oncologist · 05 Feb 2026 · doi:10.1093/oncolo/oyag029

2025

Structural alterations during fracture healing lead to void spaces developing in surrounding bone microarchitecture

Danielle E Whittier, Matthias Walle, Penny R Atkins, Caitlyn J Collins, Matthias A Zumstein, Patrik Christen, Kurt Lippuner, Ralph Müller

Journal of Bone and Mineral Research · 03 Jun 2025 · doi:10.1093/jbmr/zjaf046

Comparing linear and nonlinear finite element models of vertebral strength across the thoracolumbar spine: a benchmark from density-calibrated computed tomography

Matthias Walle, Bryn E Matheson, Steven K Boyd

GigaScience · 06 Jan 2025 · doi:10.1093/gigascience/giaf094

Using solid-state MRI and a double-tuned RF coil to quantify bone matrix and mineral densities in rat bones

Victor B. Kassey, Matthias Walle, Diana Yeritsyan, Daniel V. Kassey, Yaotang Wu, Brian D. Snyder, Edward K. Rodriguez, Jerome L. Ackerman, Ara Nazarian

JOURNAL OF MAGNETIC RESONANCE · 01 Jan 2025 · doi:10.1016/J.JMR.2025.107925

Recovery of bone microarchitecture and density four years after spaceflight: two case studies

Bryn E. Matheson, Matthias Walle, Anna-Maria Liphardt, Paul A. Hulme, Martina Heer, Sara R. Zwart, Jean D. Sibonga, Scott M. Smith, Leigh Gabel, Steven K. Boyd

NPJ MICROGRAVITY · 01 Jan 2025 · doi:10.1038/S41526-025-00511-X

Quantifying localized bone loss in clinical computed tomography using void spaces

Annabel R. Bugbird, Bryn E. Matheson, Matthias Walle, Nathan J. Neeteson, Nina Pavlovic, Callie E. Stirling, Danielle E. Whittier, Steven K. Boyd

OSTEOPOROSIS INTERNATIONAL · 01 Jan 2025 · doi:10.1007/S00198-025-07558-2

2024

Tracking of spaceflight-induced bone remodeling reveals a limited time frame for recovery of resorption sites in humans

Matthias Walle, Leigh Gabel, Danielle E. Whittier, Anna-Maria Liphardt, Paul A. Hulme, Martina Heer, Sara R. Zwart, Scott M. Smith, Jean D. Sibonga, Steven K. Boyd

Science Advances · 20 Dec 2024 · doi:10.1126/sciadv.adq3632

Quantitative ¹H Magnetic Resonance Imaging on Normal and Pathologic Rat Bones by Solid-State ¹H ZTE Sequence with Water and Fat Suppression

Víctor B. Kassey, Matthias Walle, Jonathan Egan, Diana Yeritsyan, Indeevar Beeram, …, Yaotang Wu, Brian D. Snyder, Edward K. Rodriguez, Jerome L. Ackerman, Ara Nazarian

JOURNAL OF MAGNETIC RESONANCE IMAGING · 01 Jan 2024 · doi:10.1002/JMRI.29361

Quantitative 31P magnetic resonance imaging on pathologic rat bones by ZTE at 7T

Victor B. Kassey, Matthias Walle, Jonathan Egan, Diana Yeritsyan, Indeevar Beeram, Yaotang Wu, Brian D. Snyder, Edward K. Rodriguez, Jerome L. Ackerman, Ara Nazarian

BONE · 01 Jan 2024 · doi:10.1016/J.BONE.2023.116996

Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus

Matthias Walle, Ankita Duseja, Danielle E Whittier, Tatiane Vilaca, Margaret Paggiosi, Richard Eastell, Ralph Müller, Caitlyn J Collins

JOURNAL OF BONE AND MINERAL RESEARCH · 01 Jan 2024 · doi:10.1093/JBMR/ZJAD014

A graph model to describe the network connectivity of trabecular plates and rods

Matthias Walle, Diana Yeritsyan, Mohammadreza Abbasian, Ramin Oftadeh, Ralph Müller, Ara Nazarian

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY · 01 Jan 2024 · doi:10.3389/FBIOE.2024.1384280

2023

Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo

Matthias Walle, Danielle E. Whittier, Denis Schenk, Penny R. Atkins, Michael Blauth, Philippe Zysset, Kurt Lippuner, Ralph Müller, Caitlyn J. Collins

BONE · 01 Jan 2023 · doi:10.1016/J.BONE.2023.116780

Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks

Matthias Walle, Dominic Eggemann, Penny R. Atkins, Jack J. Kendall, Kerstin Stock, Ralph Müller, Caitlyn J. Collins

BONE · 01 Jan 2023 · doi:10.1016/J.BONE.2022.116607

Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency

Francisco C. Marques, Daniele Boaretti, Matthias Walle, Ariane C. Scheuren, Friederike A. Schulte, Ralph Müller

bioRxiv · 01 Jan 2023 · doi:10.1101/2023.01.07.523082

Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency

Francisco C. Marques, Daniele Boaretti, Matthias Walle, Ariane C. Scheuren, Friederike A. Schulte, Ralph Müller

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY · 01 Jan 2023 · doi:10.3389/FBIOE.2023.1140673

A multi-stack registration technique to improve measurement accuracy and precision across longitudinal HR-pQCT scans

Danielle E. Whittier, Matthias Walle, Denis Schenk, Penny R. Atkins, Caitlyn J. Collins, Philippe Zysset, Kurt Lippuner, Ralph Müller

BONE · 01 Jan 2023 · doi:10.1016/J.BONE.2023.116893

2022

Meta-analysis of Diabetes Mellitus-Associated Differences in Bone Structure Assessed by High-Resolution Peripheral Quantitative Computed Tomography

Matthias Walle, Danielle E. Whittier, Morten Frost, Ralph Müller, Caitlyn J. Collins

CURRENT OSTEOPOROSIS REPORTS · 01 Jan 2022 · doi:10.1007/S11914-022-00755-6

2021

Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo

Matthias Walle, Francisco C. Marques, Nicholas Ohs, Michael Blauth, Ralph Müller, Caitlyn J. Collins

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY · 01 Jan 2021 · doi:10.3389/FBIOE.2021.677985

Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect

Angad Malhotra, Matthias Walle, Graeme R. Paul, Gisela A. Kuhn, Ralph Müller

SCIENTIFIC REPORTS · 01 Jan 2021 · doi:10.1038/S41598-021-81132-8