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Quantitative Imaging for Bone and Joint Research

Publications

Research Highlights

Tracking of spaceflight-induced bone remodeling reveals a limited time frame for recovery of resorption sites in humans

Published in Science Advances, 2024

This study reveals that bone resorption during spaceflight exceeds formation, and recovery upon return to Earth is limited, indicating a critical window for bone remodeling in astronauts.

Recommended citation: Walle M, Gabel L, Whittier DE, Liphardt AM, Hulme PA, Heer M, Zwart SR, Smith SM, Sibonga JD, Boyd SK. Tracking of spaceflight-induced bone remodeling reveals a limited time frame for recovery of resorption sites in humans. Sci Adv. 2024;10(51):eadq3632.
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Bone remodelling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus.

Published in Journal of Bone and Mineral Research, 2024

Recent studies indicate that type 1 diabetes mellitus impairs bone remodeling by reducing the skeleton’s responsiveness to mechanical stimuli, leading to significantly lower bone formation and resorption rates compared to healthy controls.

Recommended citation: Walle M, Duseja A, Whittier DE, Vilaca T Paggiosi M, Eastell R, Müller R, Collins CJ. Bone remodelling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus. Journal of Bone and Mineral Research
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Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo.

Published in Bone, 2023

Local mechanical forces in bone play an important role in bone health and adaptation.

Recommended citation: Walle M, Whittier DE, Schenk D, Atkins PR, Blauth M, Zysset P, Lippuner K, Müller R, Collins CJ. Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo. Bone. 2023 Jul 1;172:116780.
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Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks.

Published in Bone, 2023

When patients move during a specific type of bone scan called high-resolution peripheral quantitative CT (HR-pQCT), it reduces the quality of the images.

Recommended citation: Walle M, Eggemann D, Atkins PR, Kendall JJ, Stock K, Müller R, Collins CJ. Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks. Bone. 2023 Jan 1;166:116607.
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Meta-analysis of diabetes mellitus-associated differences in bone structure assessed by high-resolution peripheral quantitative computed tomography.

Published in Current Osteoporosis Reports, 2022

Diabetes leads to higher blood sugar and changes in how the body can process sugar.

Recommended citation: Whittier DE, Frost M, Müller R, Collins CJ. Meta-analysis of diabetes mellitus-associated differences in bone structure assessed by high-resolution peripheral quantitative computed tomography. Current Osteoporosis Reports. 2022 Dec;20(6):398-409.
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Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo

Published in Front. Bioeng. Biotechnol., 2021

Despite steadily improving treatments for bone diseases, prescribed therapies are not always successful in certain patients.

Recommended citation: Walle M, Marques FC, Ohs N, Blauth M, Müller R and Collins CJ (2021) Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo. Front. Bioeng. Biotechnol. 9:677985. doi: 10.3389/fbioe.2021.677985
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Publications

You can also find my articles on my Google Scholar profile.